Provigil (Modafinil)

Provigil (Modafinil)

Provongil is designed to cope with drowsiness caused by sleep disorders, and is recognized as very effective for maintaining vigor. Using Provigil allows you to maintain a vigorous state in case of need and at the same time does not disturb sleep (taking the pill Provigil in the morning will not prevent a person from falling asleep at night). Taking Provigil can significantly improve a person’s condition, his daily functioning and concentration, which ultimately has a beneficial effect on the patient’s quality of life. The effectiveness of Provigil was tested and scientifically proven in the course of several clinical studies, the participants of which were also patients with multiple sclerosis, suffering from excessive fatigue.

Properties and mechanism of action

Modafinil affects various parts of the brain. Probably the most important effect is an increase in the speed of mental reactions. This effect refers to the lower part of the diencephalon, the hypothalamus, where the activation of the nerve pathways occurs, in which the action of orexin / hypocretins, which play an important role in the regulation of sleep-wakefulness as mediators, is realized.

In addition, it activates the sympathetic alpha-1 receptors of the central nervous system, increases the activity of stimulation of glutamine and histamine transmitters, and also enhances the effects of serotonin in the cerebral cortex.

Moreover, it reduces the activity of those inhibitory nerve cells in which gamma-aminobutyric acid acts as a transmitter.

Indications for use

The main indication for use is narcolepsy (sleep disturbance with a strong manifestation of drowsiness), pathological drowsiness, chronic overwork, apnea. The use of a medicinal substance is justified during shift work, to increase psychophysical endurance, can be used comprehensively in the treatment of depressive syndrome. Modafinil can show a positive result when testing athletes for doping - this should be considered when taking the drug.

Contradictions:

Contraindications to the use of the drug are individual intolerance to the drug, a mandatory consultation with a doctor in the presence of severe cardiovascular diseases, liver pathology.

Modafinil, when used simultaneously with yohimbine, increases the heart rate and increases blood pressure.

It also reduces the effect of certain birth control pills, which can lead to an unplanned pregnancy.

Dosage

Dosage form: 100mg, 200mg oblong, white tablets.

Provigil belongs to the prescription category of drugs. In America, where its use is most popular, its distribution is strictly controlled. The dosage of the drug is prescribed exclusively by the attending physician, you can not take the drug on your own without a prescription. A universal dosage regimen is 4 mg per kilogram of body weight.

Active components and method of admission

The main active ingredient of the drug Provigil (Provigil) is Modafinil. It is a central psychostimulant that affects mood, increases energy and promotes enhanced dopamine release. Due to the special mechanism of action, Modafinil does not cause euphoria, does not raise blood pressure and does not provoke a hangover syndrome and "catch-up" of lost sleep.

The method of administration of the drug is about 2-3 tablets in the morning or at lunch. For a quick effect, it is recommended to take Provigil on an empty stomach. A consultation with a doctor is required!

Side effects

Whatever the positive properties of Provigil, its side effects are very significant. They are found relatively more often than most other nootropics, but it should be noted that the effectiveness of modafinil against their background is stronger.

The most common side effect is a headache - 34% of all side effects.

Also a danger is severe depletion of the body. Regular lack of sleep, which is stopped by taking modafinil, leads to serious disorders and an imbalance in the body.

An increase in the level of histamine reduces the body's resistance to allergic reactions, which can lead to banal hives, peeling of the skin, as well as to more serious complications. These include severe allergies involving liver or blood cells, the formation of edema on the face, lips, legs, throat, Quincke's edema, Steven-Jones syndrome, erythema polymorphic, Lyell's syndrome, DRESS syndrome and other possible consequences.

Other side effects include insomnia, nausea, diarrhea, dyspeptic disorders, back pain, anxiety, anxiety, fever, shortness of breath, yellowing of the skin and sclera, dark urine.