
Provigil (Modafinil)
Not in stock
This product is shipped from EU
Provigil (Modafinil)
Provongil
is designed to cope with drowsiness caused by sleep disorders, and is
recognized as very effective for maintaining vigor. Using Provigil allows you
to maintain a vigorous state in case of need and at the same time does not
disturb sleep (taking the pill Provigil in the morning will not prevent a
person from falling asleep at night). Taking Provigil can significantly improve
a person’s condition, his daily functioning and concentration, which ultimately
has a beneficial effect on the patient’s quality of life. The effectiveness of Provigil
was tested and scientifically proven in the course of several clinical studies,
the participants of which were also patients with multiple sclerosis, suffering
from excessive fatigue.
Properties and
mechanism of action
Modafinil
affects various parts of the brain. Probably the most important effect is an
increase in the speed of mental reactions. This effect refers to the lower part
of the diencephalon, the hypothalamus, where the activation of the nerve
pathways occurs, in which the action of orexin / hypocretins, which play an
important role in the regulation of sleep-wakefulness as mediators, is
realized.
In
addition, it activates the sympathetic alpha-1 receptors of the central nervous
system, increases the activity of stimulation of glutamine and histamine
transmitters, and also enhances the effects of serotonin in the cerebral
cortex.
Moreover,
it reduces the activity of those inhibitory nerve cells in which
gamma-aminobutyric acid acts as a transmitter.
Indications for use
The
main indication for use is narcolepsy (sleep disturbance with a strong
manifestation of drowsiness), pathological drowsiness, chronic overwork, apnea.
The use of a medicinal substance is justified during shift work, to increase
psychophysical endurance, can be used comprehensively in the treatment of
depressive syndrome. Modafinil can show a positive result when testing athletes
for doping - this should be considered when taking the drug.
Contradictions:
Contraindications to the use of the drug are individual
intolerance to the drug, a mandatory consultation with a doctor in the presence
of severe cardiovascular diseases, liver pathology.
Modafinil, when used simultaneously with yohimbine,
increases the heart rate and increases blood pressure.
It also reduces the effect of certain birth control
pills, which can lead to an unplanned pregnancy.
Dosage
Dosage
form: 100mg, 200mg oblong, white tablets.
Provigil
belongs to the prescription category of drugs. In America, where its use is
most popular, its distribution is strictly controlled. The dosage of the drug
is prescribed exclusively by the attending physician, you can not take the drug
on your own without a prescription. A universal dosage regimen is 4 mg per
kilogram of body weight.
Active components and
method of admission
The
main active ingredient of the drug Provigil (Provigil) is Modafinil. It is a
central psychostimulant that affects mood, increases energy and promotes
enhanced dopamine release. Due to the special mechanism of action, Modafinil
does not cause euphoria, does not raise blood pressure and does not provoke a
hangover syndrome and "catch-up" of lost sleep.
The
method of administration of the drug is about 2-3 tablets in the morning or at
lunch. For a quick effect, it is recommended to take Provigil on an empty
stomach. A consultation with a doctor is required!
Side effects
Whatever the positive properties of Provigil, its side
effects are very significant. They are found relatively more often than most
other nootropics, but it should be noted that the effectiveness of modafinil
against their background is stronger.
The most common side effect is a headache - 34% of all
side effects.
Also a danger is severe depletion of the body. Regular
lack of sleep, which is stopped by taking modafinil, leads to serious disorders
and an imbalance in the body.
An increase in the level of histamine reduces the
body's resistance to allergic reactions, which can lead to banal hives, peeling
of the skin, as well as to more serious complications. These include severe
allergies involving liver or blood cells, the formation of edema on the face,
lips, legs, throat, Quincke's edema, Steven-Jones syndrome, erythema
polymorphic, Lyell's syndrome, DRESS syndrome and other possible consequences.
Other side effects include insomnia, nausea, diarrhea,
dyspeptic disorders, back pain, anxiety, anxiety, fever, shortness of breath,
yellowing of the skin and sclera, dark urine.